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The Shaping of Modern Human Immune Systems by Multiregional Admixture with Archaic Humans

A study published online this week suggests that mating between human ancestors and other now-extinct groups boosted the immune systems of early Europeans and Asians. The paper finds that archaic people, namely Neandertals and Denisovans, contributed more than half of the alleles that code for proteins made by the human leukocyte antigen system (HLA), which helps the immune system recognize pathogens.

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